Senior Scientist – Histology of respiratory diseases

We are recruiting a Senior Scientist with expertise in histology for a consulting assignment at AstraZeneca's R&D site in Gothenburg. This is an exciting opportunity to join the Bioscience Department within Immunology and contribute directly to respiratory drug discovery projects in a world-class research environment.

About the assignment

As a Senior Scientist you will be a key member of a highly motivated team, working closely with departments focused on Target Translational Science, Bioscience in vitro assays, and Drug Metabolism/Pharmacokinetics. The role is partly lab-based, with responsibility for planning, performing, and evaluating histological analyses, as well as driving the establishment of new techniques.

You will characterize and validate target expression and evaluate drug-target engagement in both patient and in vivo tissue samples, independently assess and report data, and present findings in cross-functional project meetings.

What we are looking for

REQUIRED

• PhD in a relevant discipline (Bioscience, Respiratory, or related field)

• Strong hands-on histology skills: immunohistochemistry, histochemistry, in situ hybridization including RNAscope

• Experience with automated staining platforms (e.g. Ventana Discovery Ultra, Leica Bond)

• Proficiency in image analysis platforms (e.g. Visiopharm, Halo)

• Solid understanding of statistical methods, quality control, and data reporting

• Excellent written and oral communication skills in English

DESIRABLE

• Knowledge of respiratory diseases such as asthma, COPD, or IPF

• Experience in histology scoring and histomorphometry

• Familiarity with deep learning image analysis, e.g. image segmentation and classification

• Knowledge of advanced histological techniques: spatial transcriptomics, multiplex staining, tissue optical clearing

• Scripting experience in Python or R

• Background in pharmacology, physiology, or immunology